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Prog Growth Factor Res. 1989;1(1):33-48.

The gene structure of the insulin-like growth factor family.

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Laboratory for Physiological Chemistry, State University of Utrecht, The Netherlands.


The insulin-like growth factors (IGF) constitute a family of proteins with insulin-like and growth-stimulating properties. The best characterized members of this family are IGF-I, a protein of 70 amino acids which plays an important role in post-natal growth, and IGF-II, a 67 amino acid protein which is most likely involved in fetal development. The gene structure of IGF-II has been elucidated for the human and the rat and shows extensive interspecies homologies. The gene structure of IGF-I has only partially been established. A striking feature of the IGF genes is that they are controlled by multiple promoters which are expressed in a tissue-specific and development-dependent way.

[Indexed for MEDLINE]

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