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Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8643-8. doi: 10.1073/pnas.1400178111. Epub 2014 May 27.

Impact of puberty on the evolution of cerebral perfusion during adolescence.

Author information

1
Brain and Behavior Laboratory, Department of Psychiatry,Department of Radiology, Center for Biomedical Image Computing and Analytics, sattertt@upenn.edu.
2
Department of Radiology, Center for Biomedical Image Computing and Analytics,Department of Biostatistics and Epidemiology.
3
Brain and Behavior Laboratory, Department of Psychiatry,Department of Radiology, Center for Biomedical Image Computing and Analytics.
4
Brain and Behavior Laboratory, Department of Psychiatry.
5
Department of Radiology, Center for Biomedical Image Computing and Analytics,Department of Radiology, Center for Magnetic Resonance and Optical Imaging, and.
6
Department of Radiology, Center for Biomedical Image Computing and Analytics.
7
Department of Neurology, Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA 19104;
8
Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104; and.
9
Brain and Behavior Laboratory, Department of Psychiatry,Department of Radiology, Center for Biomedical Image Computing and Analytics,Philadelphia Veterans Administration Medical Center, Philadelphia, PA 19104.
10
Brain and Behavior Laboratory, Department of Psychiatry,Department of Biostatistics and Epidemiology.

Abstract

Puberty is the defining biological process of adolescent development, yet its effects on fundamental properties of brain physiology such as cerebral blood flow (CBF) have never been investigated. Capitalizing on a sample of 922 youths ages 8-22 y imaged using arterial spin labeled MRI as part of the Philadelphia Neurodevelopmental Cohort, we studied normative developmental differences in cerebral perfusion in males and females, as well as specific associations between puberty and CBF. Males and females had conspicuously divergent nonlinear trajectories in CBF evolution with development as modeled by penalized splines. Seventeen brain regions, including hubs of the executive and default mode networks, showed a robust nonlinear age-by-sex interaction that surpassed Bonferroni correction. Notably, within these regions the decline in CBF was similar between males and females in early puberty and only diverged in midpuberty, with CBF actually increasing in females. Taken together, these results delineate sex-specific growth curves for CBF during youth and for the first time to our knowledge link such differential patterns of development to the effects of puberty.

PMID:
24912164
PMCID:
PMC4060665
DOI:
10.1073/pnas.1400178111
[Indexed for MEDLINE]
Free PMC Article
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