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Curr Eye Res. 2014 Aug;39(8):823-9. doi: 10.3109/02713683.2011.556299. Epub 2014 Jun 9.

Evaluation of oxidative stress markers in aqueous humor of primary open angle glaucoma and primary angle closure glaucoma patients.

Author information

1
Department of Ocular Biochemistry, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi , India and.

Abstract

PURPOSE:

The present study was designed to determine the levels of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and non-enzymatic antioxidants (vitamins C and E) in aqueous humor of primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG) patients.

MATERIALS AND METHODS:

In this study, aqueous humor of POAG (n = 30) and PACG (n = 30) patients was obtained. For control, aqueous humor of 30 age-matched cataract patients (n = 30) was collected. Activities of antioxidant enzymes and non-enzymatic antioxidants levels were measured spectrophotometrically.

RESULTS:

A significant increase in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities was found in aqueous humor of POAG and PACG patients as compared to cataract patients (p < 0.001). No significant changes were observed in catalase activity. The levels of vitamins C and E were significantly lower in the aqueous humor of POAG and PACG as compared to cataract patients (p < 0.001).

CONCLUSION:

These results suggest that a significant increase in oxidative stress may play a role in the pathogenesis of POAG and PACG. Determination of oxidative stress in aqueous humor may help in understanding the course of this disease, and oxidative damage might be a relevant target for both prevention and therapy.

KEYWORDS:

Antioxidant enzymes; cataract; glaucoma; vitamin C; vitamin E

PMID:
24912005
DOI:
10.3109/02713683.2011.556299
[Indexed for MEDLINE]

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