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Int Rev Immunol. 2014 Oct;33(5):402-16. doi: 10.3109/08830185.2014.917412. Epub 2014 Jun 9.

Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses.

Author information

1
1Instituto Nacional de Câncer, Programa de Carcinogênese Molecular, Coordenação de Pesquisa, Rio de Janeiro, Brazil.

Abstract

Adoptive cell transfer (ACT) is emerging as a powerful modality of cancer treatment. While ACT has proved able to induce massive clinical responses, genetic modification of T lymphocytes further improved clinical responses obtained. One of the major current limitations of ACT is the inability to discern healthy from malignant cells, leading to on target/off tumor responses that can limit its application. We here discuss some of the approaches currently under development and potential solutions to circumvent these limitations and extend this potentially curative therapy to different tumors by targeting a variety of antigens.

KEYWORDS:

adoptive cell therapy; cancer; chimeric antigen receptor; gene therapy; immuno- therapy; off-target; tumor antigen

PMID:
24911925
DOI:
10.3109/08830185.2014.917412
[Indexed for MEDLINE]
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