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Life Sci. 2014 Jul 17;108(2):109-15. doi: 10.1016/j.lfs.2014.05.018. Epub 2014 Jun 5.

Lavender essential oil inhalation suppresses allergic airway inflammation and mucous cell hyperplasia in a murine model of asthma.

Author information

1
Field of Medical Technology, Okayama University Graduate School of Health Sciences, Okayama, Japan.
2
Field of Medical Technology, Okayama University Graduate School of Health Sciences, Okayama, Japan. Electronic address: m_shiba@md.okayama-u.ac.jp.
3
Department of Hematology, Oncology, Allergy, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, Pharmaceutical Sciences, Okayama, Japan.

Abstract

AIMS:

Lavender essential oil (Lvn) has been reported to have anti-inflammatory effects. Bronchial asthma is characterized by bronchial allergic inflammation with airway remodeling. Therefore, we evaluated the anti-inflammatory effect of Lvn on experimentally induced bronchial asthma in a murine model.

MAIN METHODS:

BALB/c mice were sensitized by an intraperitoneal injection of ovalbumin (OVA) at days 0 and 14, and subsequently challenged with nebulized OVA on days 28-30 (Control-Asthma group). Mice in the treatment group inhaled Lvn on days 14-31 (Lvn-Asthma group). The allergic inflammatory response was determined on days 32 and 33.

KEY FINDINGS:

An increase in airway resistance was inhibited in the Lvn-Asthma group than in the Control-Asthma group. The Lvn-Asthma group showed lower total cell numbers and eosinophils in bronchoalveolar lavage (BAL) fluids and peribronchial and perivascular tissues when compared with the Control-Asthma group. The Lvn-Asthma group also had less mucin hyperplasia than the Control-Asthma group. Furthermore, the Lvn-Asthma group showed lower interleukin (IL)-5 and IL-13 cytokine levels in BAL fluids, as well as reduced IL-4 and IL-5 mRNA expression in lung tissue, compared with the Control-Asthma group and determined by FlowCytomix and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively. In addition, Lvn inhalation reduced Muc5b mRNA expression in the lungs without significantly changing the expression of Muc5ac mRNA.

SIGNIFICANCE:

Lvn inhibits allergic inflammation and mucous cell hyperplasia with suppression of T-helper-2 cell cytokines and Muc5b expression in a murine model of asthma. Consequently, Lvn may be useful as an alternative medicine for bronchial asthma.

KEYWORDS:

Alternative medicine; Asthma; Cytokines; Lavender; Mucin

PMID:
24909715
DOI:
10.1016/j.lfs.2014.05.018
[Indexed for MEDLINE]

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