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Inhal Toxicol. 2014 Jul;26(8):435-51. doi: 10.3109/08958378.2014.905660. Epub 2014 Jun 9.

Inhalation carcinogenicity of dichloromethane in rats and mice.

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  • 1Japan Bioassay Research Center, Japan Industrial Safety and Health Association , Kanagawa , Japan.

Abstract

The carcinogenicity of inhaled dichloromethane (DCM) was examined by exposing groups of 50 F344/DuCrj rats and 50 Crj: BDF1 mice of both sexes to 0, 1000, 2000, or 4000 ppm (w/w) DCM-containing aerosol for 2 years. Inhalation of DCM resulted in increased incidences of subcutis fibromas, mammary gland fibroadenoma, and peritoneum mesotheliomas in male rats; mammary gland fibroadenomas in female rats; and bronchiolar-alveolar adenomas and carcinomas in the lung and hepatocellular adenomas and carcinomas in male and female mice. These results clearly indicate that inhaled DCM is carcinogenic in F344/DuCrj (SPF) rats and Crj: BDF1 (SPF) mice.

KEYWORDS:

Carcinogenicity; dichloromethane; inhalation; mouse; rat

PMID:
24909451
DOI:
10.3109/08958378.2014.905660
[PubMed - indexed for MEDLINE]
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