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Environ Toxicol Pharmacol. 2014 Jul;38(1):58-70. doi: 10.1016/j.etap.2014.05.002. Epub 2014 May 14.

Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells.

Author information

1
Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research, Balanagar, Hyderabad, Andhra Pradesh 500 037, India.
2
Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research, Balanagar, Hyderabad, Andhra Pradesh 500 037, India. Electronic address: vgmnaidu@niperhyd.ac.in.
3
Pharmacology Division, Indian Institute of Chemical Technology, Habsiguda, Hyderabad, Andhra Pradesh, India.

Abstract

The present study was aimed to evaluvate the apoptogenic potential of ethanolic extract of leaves from Boswellia ovalifoliolata (BL EthOH) and to unravel the molecular mechanisms implicated in apoptosis of Triple Negative Breast Cancer (TNBC) cells. BL EthOH was cytotoxic against TNBC cells like MDA-MB-231 and MDA-MB-453 with IC₅₀ concentrations 67.48 ± 5.45 and 70.03 ± 4.76 μg/ml, respectively. Apoptotic studies showed that BL EthOH was able to induce apoptosis and western blot studies demonstrated that BL EthOH significantly decreased the Phospho-NF-κB (ser536), PCNA, anti-apoptotic protein Bcl-2 expression and increased the expression of pro-apoptotic protein Bax, in MDA-MB-231 and MDA-MB-453 cell lines when compared with untreated cells. Besides, BL EthOH has synergistic chemosensitizing effects on TNBC cells and increased the cytotoxicity of doxorubicin and cisplatin.

KEYWORDS:

Boswellia ovalifoliolata; Chemoresistance; NF-κB; ROS; S-phase; TNBC

PMID:
24908637
DOI:
10.1016/j.etap.2014.05.002
[Indexed for MEDLINE]

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