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Environ Toxicol Pharmacol. 2014 Jul;38(1):51-7. doi: 10.1016/j.etap.2014.04.004. Epub 2014 Apr 12.

Association between some endocrine-disrupting chemicals and childhood obesity in biological samples of young girls: a cross-sectional study.

Author information

1
Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea; Department of Chemistry, Interdisciplinary Program of Integrated Biotechnology, Sogang University, Shinsoo-dong, Mapo-gu, Seoul 121-742, Republic of Korea.
2
Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
3
Department of Health Environment, Hoseo Graduate School of Venture, Seoul, Republic of Korea.
4
Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea. Electronic address: yjkim@kist.re.kr.

Abstract

Childhood obesity, a major public health concern, has increased worldwide. Endocrine-disrupting chemicals (EDCs) have recently received attention as a cause of obesity. A cross-sectional study using logistic regression was conducted to investigate the association between some endocrine disrupting chemicals and obesity in young girls. Endogenous steroids expected to be associated with EDCs were also investigated. The target compounds included 7 phthalates (MEP, DBP, MBP, DEHP, MEHP, PA and MBzP), 2 alkylphenols (4-NP and t-OP), bisphenol A and 9 endogenous steroids (DHT, epi-T, T, DHEA, A, P, E1, E2 and E3). PA in urine and MEP, DBP and PA in serum showed statistically significant differences between the control and obese groups, those compounds were considered to be associated with obesity. In addition, DHEA in serum showed a statistically significant difference between obese and control groups. We concluded that these substances can affect the development of obesity.

KEYWORDS:

Alkylphenol; Bisphenol A; Childhood obesity; Endocrine disrupting chemicals; Endogenous steroids; Phthalate

PMID:
24908636
DOI:
10.1016/j.etap.2014.04.004
[Indexed for MEDLINE]

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