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Neuron. 2014 Jun 4;82(5):966-80. doi: 10.1016/j.neuron.2014.04.042.

Amygdala microcircuits controlling learned fear.

Author information

1
Institute of Neurophysiology, Neuroscience Center, Goethe-University, Frankfurt, Germany.
2
Center for Molecular & Behavioral Neuroscience, Rutgers State University, 197 University Avenue, Newark, NJ 07102, USA. Electronic address: pare@andromeda.rutgers.edu.

Abstract

We review recent work on the role of intrinsic amygdala networks in the regulation of classically conditioned defensive behaviors, commonly known as conditioned fear. These new developments highlight how conditioned fear depends on far more complex networks than initially envisioned. Indeed, multiple parallel inhibitory and excitatory circuits are differentially recruited during the expression versus extinction of conditioned fear. Moreover, shifts between expression and extinction circuits involve coordinated interactions with different regions of the medial prefrontal cortex. However, key areas of uncertainty remain, particularly with respect to the connectivity of the different cell types. Filling these gaps in our knowledge is important because much evidence indicates that human anxiety disorders results from an abnormal regulation of the networks supporting fear learning.

PMID:
24908482
PMCID:
PMC4103014
DOI:
10.1016/j.neuron.2014.04.042
[Indexed for MEDLINE]
Free PMC Article
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