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Curr Opin Neurobiol. 2014 Dec;29:48-56. doi: 10.1016/j.conb.2014.05.003. Epub 2014 Jun 5.

Neuromodulation of neurons and synapses.

Author information

1
Federated Department of Biological Sciences, New Jersey Institute of Technology and Rutgers University, 323 Martin Luther King Blvd, Newark, NJ 07102, United States. Electronic address: farzan@njit.edu.
2
Federated Department of Biological Sciences, New Jersey Institute of Technology and Rutgers University, 323 Martin Luther King Blvd, Newark, NJ 07102, United States.

Abstract

Neuromodulation underlies the flexibility of neural circuit operation and behavior. Individual neuromodulators can have divergent actions in a neuron by targeting multiple physiological mechanisms. Conversely, multiple neuromodulators may have convergent actions through overlapping targets. The divergent and convergent neuromodulator actions can be unambiguously synergistic or antagonistic, but neuromodulation often entails balanced adjustment of nonlinear membrane and synaptic properties by targeting ion channel and synaptic dynamics rather than just excitability or synaptic strength. In addition, neuromodulators can exert effects at multiple timescales, from short-term adjustments of neuron and synapse function to persistent long-term regulation. This short review summarizes some highlights of the diverse actions of neuromodulators on ion channel and synaptic properties.

PMID:
24907657
PMCID:
PMC4252488
DOI:
10.1016/j.conb.2014.05.003
[Indexed for MEDLINE]
Free PMC Article

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