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Neuroimage. 2014 Oct 15;100:347-57. doi: 10.1016/j.neuroimage.2014.05.077. Epub 2014 Jun 5.

Microstructural differences in the thalamus and thalamic radiations in the congenitally deaf.

Author information

1
Cognitive and Perceptual Brain Sciences, 26 Bedford Way, University College London, London WC1H 0AP, UK. Electronic address: c.rebeccalyness@gmail.com.
2
Institute of Child Health, University College London, London WC1N 1EH, UK.
3
Cognitive and Perceptual Brain Sciences, 26 Bedford Way, University College London, London WC1H 0AP, UK; Birkbeck, University of London, Malet Street, Bloomsbury, London WC1E 7HX, UK.
4
Deafness, Cognition & Language Research Centre, 49 Gordon Square, University College London, London WC1H 0PD, UK; Institute of Cognitive Neuroscience, 17 Queen Square, University College London, London WC1H 3AR, UK.

Abstract

There is evidence of both crossmodal and intermodal plasticity in the deaf brain. Here, we investigated whether sub-cortical plasticity, specifically of the thalamus, contributed to this reorganisation. We contrasted diffusion weighted magnetic resonance imaging data from 13 congenitally deaf and 13 hearing participants, all of whom had learnt British Sign Language after 10 years of age. Connectivity based segmentation of the thalamus revealed changes to mean and radial diffusivity in occipital and frontal regions, which may be linked to enhanced peripheral visual acuity, and differences in how visual attention is deployed in the deaf group. Using probabilistic tractography, tracts were traced between the thalamus and its cortical targets, and microstructural measurements were extracted from these tracts. Group differences were found in microstructural measurements of occipital, frontal, somatosensory, motor and parietal thalamo-cortical tracts. Our findings suggest that there is sub-cortical plasticity in the deaf brain, and that white matter alterations can be found throughout the deaf brain, rather than being restricted to, or focussed in the auditory cortex.

KEYWORDS:

Deafness; Diffusion weighted MRI; Neuroplasticity; Thalamus

PMID:
24907483
PMCID:
PMC4148523
DOI:
10.1016/j.neuroimage.2014.05.077
[Indexed for MEDLINE]
Free PMC Article

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