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Curr Opin Cell Biol. 2014 Oct;30:17-24. doi: 10.1016/j.ceb.2014.05.002. Epub 2014 Jun 5.

T cell migration in intact lymph nodes in vivo.

Author information

1
Centenary Institute of Cancer Medicine and Cell Biology, Immune Imaging Program, Locked Bag 6, Newtown, NSW 2042, Australia.
2
Centenary Institute of Cancer Medicine and Cell Biology, Immune Imaging Program, Locked Bag 6, Newtown, NSW 2042, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia.
3
Centenary Institute of Cancer Medicine and Cell Biology, Immune Imaging Program, Locked Bag 6, Newtown, NSW 2042, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia; Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. Electronic address: w.weninger@centenary.org.au.

Abstract

In the lymph node, T cells migrate rapidly and with striking versatility in a continuous scan for antigen presenting dendritic cells. The scanning process is greatly facilitated by the lymph node structure and composition. In vivo imaging has been instrumental in deciphering the spatiotemporal dynamics of intranodal T cell migration in both health and disease. Here we review recent developments in uncovering the migration modes employed by T cells in the lymph node, the underlying molecular mechanisms, and the scanning strategies utilised by T cells to ensure a timely response to antigenic stimuli.

PMID:
24907445
DOI:
10.1016/j.ceb.2014.05.002
[Indexed for MEDLINE]
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