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J Urol. 2014 Dec;192(6):1679-85. doi: 10.1016/j.juro.2014.05.102. Epub 2014 Jun 5.

The overlap and distinction of self-reported symptoms between interstitial cystitis/bladder pain syndrome and overactive bladder: a questionnaire based analysis.

Author information

1
Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri. Electronic address: laih@wustl.edu.
2
Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
3
Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
4
Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, Missouri.

Abstract

PURPOSE:

We compared symptoms between interstitial cystitis/bladder pain syndrome and overactive bladder based on patient self-reported symptoms on validated questionnaires.

MATERIALS AND METHODS:

We prospectively recruited 26 patients diagnosed with interstitial cystitis/bladder pain syndrome, 53 diagnosed with overactive bladder and 30 healthy controls to participate in a questionnaire based study that inquired about lower urinary tract symptoms. The questionnaires used were GUPI, ICSI, ICPI, ICIQ-OAB, ICIQ-UI, IUSS, numerical rating scales of the severity of bladder pain, pressure or discomfort, and numerical rating scale of the severity of urgency and frequency symptoms.

RESULTS:

On univariate analysis patients with interstitial cystitis/bladder pain syndrome reported significantly more severe pain symptoms than those with overactive bladder. Patients with overactive bladder reported significantly more severe urinary incontinence symptoms than those with interstitial cystitis/bladder pain syndrome. There was no difference in frequency and urgency severity between the groups. Surprisingly, 33% of patients with overactive bladder reported pain or discomfort when the bladder filled and 46% with interstitial cystitis/bladder pain syndrome reported urgency incontinence. On multivariate analysis ICIQ-UI total scores (p = 0.01) and bladder pain severity on the numerical rating scale (p <0.01) distinguished the 2 conditions with 90.6% sensitivity and 96.1% specificity. Overactive bladder had higher ICIQ-UI and lower numerical rating scale pain scores.

CONCLUSIONS:

There is considerable overlap of self-reported symptoms between interstitial cystitis/bladder pain syndrome and overactive bladder. This overlap raises the possibility that the 2 conditions represent a continuum of a bladder hypersensitivity syndrome.

KEYWORDS:

cystitis; diagnosis; interstitial; lower urinary tract symptoms; overactive; questionnaires; urinary bladder

Comment in

PMID:
24907443
PMCID:
PMC4419783
DOI:
10.1016/j.juro.2014.05.102
[Indexed for MEDLINE]
Free PMC Article

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