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Int J Biochem Cell Biol. 2014 Sep;54:312-7. doi: 10.1016/j.biocel.2014.05.040. Epub 2014 Jun 5.

microRNA-7: a tumor suppressor miRNA with therapeutic potential.

Author information

1
Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research and University of Western Australia Centre for Medical Research, Perth, WA 6000, Australia.
2
Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA.
3
Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research and University of Western Australia Centre for Medical Research, Perth, WA 6000, Australia; School of Medicine and Pharmacology, the University of Western Australia, Nedlands, WA 6009, Australia.
4
Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research and University of Western Australia Centre for Medical Research, Perth, WA 6000, Australia; School of Medicine and Pharmacology, the University of Western Australia, Nedlands, WA 6009, Australia. Electronic address: peter.leedman@perkins.uwa.edu.au.

Abstract

microRNAs are a family of endogenous, short, non-coding RNAs that play critical roles in regulating gene expression for key cellular processes in normal and abnormal physiology. microRNA-7 is a 23 nucleotide miRNA whose expression is tightly regulated and restricted predominantly to the brain, spleen and pancreas. Reduced levels of miR-7 have been linked to the development of cancer and metastasis. As a tumor suppressor, miR-7 functions to co-ordinately downregulate a number of direct (e.g. the epidermal growth factor receptor) and indirect (e.g. phospho-Akt) growth promoting targets to decrease tumor growth in vitro and in vivo. In addition, miR-7 can increase the sensitivity of treatment-resistant cancer cells to therapeutics and inhibit metastasis. These data suggest that replacement of miR-7 ('miRNA replacement therapy') for specific human cancers could represent a new treatment approach. This article is part of a Directed Issue entitled: The Non-coding RNA Revolution.

KEYWORDS:

Cancer; Epidermal growth factor receptor; Tumor suppressor; microRNA-7

PMID:
24907395
DOI:
10.1016/j.biocel.2014.05.040
[Indexed for MEDLINE]

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