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Trends Pharmacol Sci. 2014 Aug;35(8):397-403. doi: 10.1016/j.tips.2014.05.001. Epub 2014 Jun 3.

Functional magnetic resonance imaging of intrinsic brain networks for translational drug discovery.

Author information

1
Research Service, Denver VA Medical Center, Denver, CO, USA; Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
2
Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
3
Research Service, Denver VA Medical Center, Denver, CO, USA; Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: Jason.tregellas@ucdenver.edu.

Abstract

Developing translational biomarkers is a priority for psychiatry research. Task-independent functional brain imaging is a relatively novel technique that allows examination of the brain's intrinsic networks, defined as functionally and (often) structurally connected populations of neurons whose properties reflect fundamental neurobiological organizational principles of the central nervous system. The ability to study the activity and organization of these networks has opened a promising new avenue for translational investigation, because they can be analogously examined across species and disease states. Interestingly, imaging studies have revealed shared spatial and functional characteristics of the intrinsic network architecture of the brain across species, including mice, rats, non-human primates, and humans. Using schizophrenia as an example, we show how intrinsic networks may show similar abnormalities in human diseases and animal models of these diseases, supporting their use as biomarkers in drug development.

KEYWORDS:

biomarker; connectivity; graph theory; neuroimaging; resting state; schizophrenia

PMID:
24906509
PMCID:
PMC4388149
DOI:
10.1016/j.tips.2014.05.001
[Indexed for MEDLINE]
Free PMC Article

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