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Daru. 2014 Jun 6;22:48. doi: 10.1186/2008-2231-22-48.

The antimicrobial effects of selenium nanoparticle-enriched probiotics and their fermented broth against Candida albicans.

Author information

1
Department of Pharmaceutical Biotechnology and Biotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. shahverd@tums.ac.ir.

Abstract

BACKGROUND:

Lactic acid bacteria are considered important probiotics for prevention of some infections. The aim of this work was to investigate the effect of selenium dioxide on the antifungal activity of Lactobacillus plantarum and L. johnsonii against Candida albicans.

METHODS:

Lactobacillus plantarum and L. johnsonii cells, grown in the presence and absence of selenium dioxide, and their cell-free spent culture media were tested for antifungal activity against C. albicans ATCC 14053 by a hole-plate diffusion method and a time-kill assay.

RESULTS:

Both L. plantarum and L. johnsonii reduced selenium dioxide to cell-associated elemental selenium nanoparticles. The cell-free spent culture media, from both Lactobacillus species that had been grown with selenium dioxide for 48 h, showed enhanced antifungal activity against C. albicans. Enhanced antifungal activity of cell biomass against C. albicans was also observed in cultures grown with selenium dioxide.

CONCLUSIONS:

Selenium dioxide-treated Lactobacillus spp. or their cell-free spent broth inhibited the growth of C. albicans and should be investigated for possible use in anti-Candida probiotic formulations in future.

PMID:
24906455
PMCID:
PMC4060857
DOI:
10.1186/2008-2231-22-48
[Indexed for MEDLINE]
Free PMC Article

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