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Methods Mol Biol. 2014;1170:229-66. doi: 10.1007/978-1-4939-0888-2_11.

The roles of cohesins in mitosis, meiosis, and human health and disease.

Author information

1
Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, MS 497, Philadelphia, PA, 19102, USA.

Abstract

Mitosis and meiosis are essential processes that occur during development. Throughout these processes, cohesion is required to keep the sister chromatids together until their separation at anaphase. Cohesion is created by multiprotein subunit complexes called cohesins. Although the subunits differ slightly in mitosis and meiosis, the canonical cohesin complex is composed of four subunits that are quite diverse. The cohesin complexes are also important for DNA repair, gene expression, development, and genome integrity. Here we provide an overview of the roles of cohesins during these different events as well as their roles in human health and disease, including the cohesinopathies. Although the exact roles and mechanisms of these proteins are still being elucidated, this review serves as a guide for the current knowledge of cohesins.

PMID:
24906316
PMCID:
PMC4495907
DOI:
10.1007/978-1-4939-0888-2_11
[Indexed for MEDLINE]
Free PMC Article

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