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Methods Mol Biol. 2014;1170:29-40. doi: 10.1007/978-1-4939-0888-2_2.

Cell cycle regulation by checkpoints.

Author information

1
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.

Abstract

Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis. Many of these mechanisms are ancient in origin and highly conserved, and hence have been heavily informed by studies in simple organisms such as the yeasts. Others have evolved in higher organisms, and control alternative cell fates with significant impact on tumor suppression. Here, we consider these different checkpoint pathways and the consequences of their dysfunction on cell fate.

PMID:
24906307
PMCID:
PMC4990352
DOI:
10.1007/978-1-4939-0888-2_2
[Indexed for MEDLINE]
Free PMC Article
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