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Cell. 2014 Jun 5;157(6):1257-61. doi: 10.1016/j.cell.2014.05.019.

Applying "gold standards" to in-vitro-derived germ cells.

Author information

1
The Jackson Laboratory, Bar Harbor, ME 04609, USA. Electronic address: maryann.handel@jax.org.
2
The Jackson Laboratory, Bar Harbor, ME 04609, USA.
3
Cornell University, Ithaca, NY 14853, USA. Electronic address: jcs92@cornell.edu.

Erratum in

  • Cell. 2014 Sep 25;159(1):216.

Abstract

Germ cells are the ultimate stem cells, and reports of their in vitro derivation generate excitement due to potential applications in reproductive medicine. To date, there is no firm evidence that meiosis, the hallmark of gametogenesis, can be faithfully replicated outside of the gonad. We propose benchmarks for evaluating in vitro derivation of germ cells, facilitating realization of their potential.

PMID:
24906145
PMCID:
PMC4338014
DOI:
10.1016/j.cell.2014.05.019
[Indexed for MEDLINE]
Free PMC Article

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