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Int J Biol Macromol. 2014 Aug;69:382-7. doi: 10.1016/j.ijbiomac.2014.05.071. Epub 2014 Jun 3.

Polyphenols from blueberries modulate inflammation cytokines in LPS-induced RAW264.7 macrophages.

Author information

1
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Institute of Agro-food Science and Technology, Shandong Academy of Agriculture Science, Jinan 250100, China.
2
Institute of Agro-food Science and Technology, Shandong Academy of Agriculture Science, Jinan 250100, China.
3
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, China. Electronic address: yqtian@jiangnan.edu.cn.
4
Institute of Agro-food Science and Technology, Shandong Academy of Agriculture Science, Jinan 250100, China. Electronic address: chenxy@saas.ac.cn.

Abstract

Polyphenols including 3-glucoside/arabinoside/galactoside-based polymers of delphinidins, petunidins, peonidins, malvidins and cyanidins are one type of biological macromolecules, which are extraordinarily rich in blueberries. Anti-inflammatory activity of blueberry polyphenols (BPPs) was investigated by using lipopolysaccharide (LPS) induced RAW264.7 macrophages. The results showed that BPPs suppressed the gene expression of IL-1β (interleukin-1β), IL-6 and IL-12p35. The inhibition effect on IL-1β and IL-6 mRNA was most obvious at the concentration of 10-200μg/mL BPPs. But the inhibition effect on IL-12p35 mRNA was increased with the increasing concentration of BPPs. When fixed at 100μg/mL BPPs, the most significant inhibition on IL-1β, IL-6 and IL-12p35 mRNA expression was detected at 12-48h. In conclusion, BPPs exhibit anti-inflammation activity by mediating and modulating the balances in pro-inflammatory cytokines of IL-1β, IL-6, and IL-12.

KEYWORDS:

Anti-inflammation; Blueberries; Polyphenols

PMID:
24905959
DOI:
10.1016/j.ijbiomac.2014.05.071
[Indexed for MEDLINE]

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