Format

Send to

Choose Destination
See comment in PubMed Commons below
J Laparoendosc Adv Surg Tech A. 2014 Jul;24(7):466-70. doi: 10.1089/lap.2013.0267. Epub 2014 Jun 6.

Laparoscopic splenectomy for primary immune thrombocytopenia: clinical outcome and prognostic factors.

Author information

1
1 Department of Surgery, "Salvador Zubirán" National Institute of Medical Sciences and Nutrition , Mexico City, Mexico .

Abstract

BACKGROUND:

Laparoscopic splenectomy (LS) is considered the standard treatment for patients with refractory primary immune thrombocytopenia (ITP).

PATIENTS AND METHODS:

All patients with ITP who underwent LS during the last 17 years and who had a minimum follow-up of 1 year were included. Several perioperative variables such as age, platelet count, and duration of preoperative therapy were recorded and analyzed, looking for potential predictive variables of clinical response.

RESULTS:

In total, 150 patients were included: 108 (72%) women and 42 (28%) men, with a mean age of 37.3±15.8 years. In the evaluation 1 year after surgery, 133 (88.7%) patients had achieved complete response, 4 (2.7%) had a response, and in 13 (8.6%) there was no response. None of the analyzed preoperative variables was identified as a predictive factor of response at 1 year. Immediate responders after surgery (≥150,000 platelets/mL during the first week) had a higher platelet count and rate of complete response at 1 year (94.2%).

CONCLUSIONS:

LS has a high success rate in patients with refractory ITP. Potential predictive indicators of success remain to be determined.

PMID:
24905792
DOI:
10.1089/lap.2013.0267
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Mary Ann Liebert, Inc.
    Loading ...
    Support Center