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J Neurosurg. 2014 Sep;121(3):709-18. doi: 10.3171/2014.4.JNS131711. Epub 2014 Jun 6.

Meta-analysis comparing deep brain stimulation of the globus pallidus and subthalamic nucleus to treat advanced Parkinson disease.

Author information

1
Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical University, YuZhong, Chong Qing, China.

Abstract

OBJECT:

Deep brain stimulation (DBS) is the surgical procedure of choice for patients with advanced Parkinson disease (PD). The globus pallidus internus (GPi) and the subthalamic nucleus (STN) are commonly targeted by this procedure. The purpose of this meta-analysis was to compare the efficacy of DBS in each region.

METHODS:

MEDLINE/PubMed, EMBASE, Web of Knowledge, and the Cochrane Library were searched for English-language studies published before April 2013.

RESULTS:

of studies investigating the efficacy and clinical outcomes of DBS of the GPi and STN for PD were analyzed.

RESULTS:

Six eligible trials containing a total of 563 patients were included in the analysis. Deep brain stimulation of the GPi or STN equally improved motor function, measured by the Unified Parkinson's Disease Rating Scale Section III (UPDRSIII) (motor section, for patients in on- and off-medication phases), within 1 year postsurgery. The change score for the on-medication phase was 0.68 (95% CI - 2.12 to 3.47, p > 0.05; 5 studies, 518 patients) and for the off-medication phase was 1.83 (95% CI - 3.12 to 6.77, p > 0.05; 5 studies, 518 patients). The UPDRS Section II (activities of daily living) scores for patients on medication improved equally in both DBS groups (p = 0.97). STN DBS allowed medication dosages to be reduced more than GPi DBS (95% CI 129.27-316.64, p < 0.00001; 5 studies, 540 patients). Psychiatric symptoms, measured by Beck Depression Inventory, 2nd edition scores, showed greater improvement from baseline after GPi DBS than after STN DBS (standardized mean difference -2.28, 95% CI -3.73 to -0.84, p = 0.002; 3 studies, 382 patients).

CONCLUSIONS:

GPi and STN DBS improve motor function and activities of daily living for PD patients. Differences in therapeutic efficacy for PD were not observed between the 2 procedures. STN DBS allowed greater reduction in medication for patients, whereas GPi DBS provided greater relief from psychiatric symptoms. An understanding of other symptomatic aspects of targeting each region and long-term observations on therapeutic effects are needed.

KEYWORDS:

ADLs = activities of daily living; BDI-II = Beck Depression Inventory, 2nd edition; DBS = deep brain stimulation; GPi = globus pallidus internus; LED = levodopa-equivalent dosage; MPTP = 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD = Parkinson disease; Parkinson disease; RCT = randomized controlled trial; SMD = standardized mean difference; STN = subthalamic nucleus; UPDRS = Unified Parkinson's Disease Rating Scale; UPDRSII, -III = UPDRS Sections II (ADLs) and III (motor section); Unified Parkinson's Disease Rating Scale; deep brain stimulation; functional neurosurgery; globus pallidus; subthalamic nucleus

PMID:
24905564
DOI:
10.3171/2014.4.JNS131711
[Indexed for MEDLINE]

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