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Pharmacol Rep. 2014 Jun;66(3):448-52. doi: 10.1016/j.pharep.2013.12.009. Epub 2014 Apr 2.

Mortality in hypertensive patients with coronary heart disease depends on chronopharmacotherapy and dipping status.

Author information

1
I Department of Cardiology, Medical University of Gdansk, Gdańsk, Poland.
2
Department of Pharmacology, Medical University of Gdansk, Gdansk, Poland. Electronic address: marwirt@interia.pl.
3
Department of Pharmacology, Medical University of Gdansk, Gdansk, Poland.

Abstract

BACKGROUND:

The goal of our study was to assess the influence of hypertension chronopharmacotherapy on diurnal blood pressure (BP) profile and mortality.

METHODS:

Subjects with established coronary heart disease (CHD) (n = 1345, mean age 63.2 ± 9.2 years) were included.

RESULTS:

Non-dipping status was related to a lack of nighttime hypertensive drug administration (OR 3.87, 95% CI 3.00-4.98). In a Cox proportional hazards regression model, non-dipping status (HR 1.17, 95% CI 1.02-1.47) and non-nighttime antihypertensive drug administration (HR 1.13, 95% CI 1.01-1.45) were predictors of all-cause mortality.

CONCLUSIONS:

The non-dipping profile of CHD patients and increased mortality were related to a lack of antihypertensive drug administration at bedtime.

KEYWORDS:

Blood pressure profile; Chronopharmacotherapy; Coronary heart disease; Hypertension; Non-dippers

PMID:
24905522
DOI:
10.1016/j.pharep.2013.12.009
[Indexed for MEDLINE]

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