Send to

Choose Destination
Liver Int. 2015 Jul;35(7):1910-6. doi: 10.1111/liv.12612. Epub 2014 Jun 23.

Major depression and suicide attempts in patients with liver disease in the United States.

Le Strat Y1,2,3,4, Le Foll B4,5,6, Dubertret C1,2,3.

Author information

Department of Psychiatry, Louis Mourier Hospital, AP-HP, Colombes, France.
Centre for Psychiatry and Neurosciences, INSERM U894, Team 1, 2 ter rue d'Alesia, Paris, 75014, France.
Sorbonne Paris Cité, Faculty of medicine, Univ Paris Diderot, France.
Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Addiction Program, Centre for Addiction and Mental Health, Toronto, Canada.
Departments of Family and Community Medicine, Psychiatry, Pharmacology and Toxicology, Institutes of Medical Sciences, University of Toronto, Toronto, Canada.



Depression is common in patients with liver disease. Moreover, alcohol use is intricately linked with both major depression and liver disease, and has also been linked with suicidal behaviours, suggesting that the alcohol use may have an intermediate role in the relationship between liver disease and major depression or suicidal behaviours. This study presents nationally representative data on the prevalence of major depression in patients with liver disease in the United States and its association with suicide attempts.


Data were drawn from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). The NESARC is a survey of 43 093 adults aged 18 years and older in the United States. Medically recognized liver diseases were self-reported, and diagnoses of major depression were based on the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV version.


The prevalence of liver disease was estimated at 0.7%. Respondents with a liver disease reported 12-month rates of major depression (17.2%) that were significantly higher than among respondents without liver disease (7.0%; Adjusted OR:2.2; CI: 1.2-4.1). Lifetime rates of suicide attempts among participants with a major depression were also higher in participants with a liver disease (33.2%) than among respondents without liver disease (13.7%; OR: 3.1; CI: 1.3-7.6).


Liver diseases are associated with major depression and suicide attempts among adults in the community. Adjustment for the amount of alcohol used or sociodemographical factors did not explain the observed association of liver disease with both major depression and suicide attempts.


depression; epidemiology; liver disease; psychiatry; suicide; survey

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center