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Cell Stem Cell. 2014 Jun 5;14(6):762-75. doi: 10.1016/j.stem.2014.05.017.

The 3D genome in transcriptional regulation and pluripotency.

Author information

1
Ludwig Institute for Cancer Research, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: dgorkin@ucsd.edu.
2
Ludwig Institute for Cancer Research, 9500 Gilman Drive, La Jolla, CA 92093, USA.
3
Ludwig Institute for Cancer Research, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, Institute of Genome Medicine, Moores Cancer Center, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: biren@ucsd.edu.

Abstract

It can be convenient to think of the genome as simply a string of nucleotides, the linear order of which encodes an organism's genetic blueprint. However, the genome does not exist as a linear entity within cells where this blueprint is actually utilized. Inside the nucleus, the genome is organized in three-dimensional (3D) space, and lineage-specific transcriptional programs that direct stem cell fate are implemented in this native 3D context. Here, we review principles of 3D genome organization in mammalian cells. We focus on the emerging relationship between genome organization and lineage-specific transcriptional regulation, which we argue are inextricably linked.

PMID:
24905166
PMCID:
PMC4107214
DOI:
10.1016/j.stem.2014.05.017
[Indexed for MEDLINE]
Free PMC Article
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