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Cell Stem Cell. 2014 Jun 5;14(6):752-61. doi: 10.1016/j.stem.2014.05.014.

Long noncoding RNAs in cell-fate programming and reprogramming.

Author information

1
Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
2
Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA. Electronic address: howchang@stanford.edu.

Abstract

In recent years, long noncoding RNAs (lncRNAs) have emerged as an important class of regulators of gene expression. lncRNAs exhibit several distinctive features that confer unique regulatory functions, including exquisite cell- and tissue-specific expression and the capacity to transduce higher-order spatial information. Here we review evidence showing that lncRNAs exert critical functions in adult tissue stem cells, including skin, brain, and muscle, as well as in developmental patterning and pluripotency. We highlight new approaches for ascribing lncRNA functions and discuss mammalian dosage compensation as a classic example of an lncRNA network coupled to stem cell differentiation.

PMID:
24905165
PMCID:
PMC4120821
DOI:
10.1016/j.stem.2014.05.014
[Indexed for MEDLINE]
Free PMC Article

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