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Cell Stem Cell. 2014 Jun 5;14(6):720-34. doi: 10.1016/j.stem.2014.05.002.

Molecular control of induced pluripotency.

Author information

1
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
2
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address: jaenisch@wi.mit.edu.

Abstract

Deciphering the mechanisms of epigenetic reprogramming provides fundamental insights into cell fate decisions, which in turn reveal strategies to make the reprogramming process increasingly efficient. Here we review recent advances in epigenetic reprogramming to pluripotency with a focus on the principal molecular regulators. We examine the trajectories connecting somatic and pluripotent cells, genetic and chemical methodologies for inducing pluripotency, the role of endogenous master transcription factors in establishing the pluripotent state, and functional interactions between reprogramming factors and epigenetic regulators. Defining the crosstalk among the diverse molecular actors implicated in cellular reprogramming presents a major challenge for future inquiry.

PMID:
24905163
PMCID:
PMC4112734
DOI:
10.1016/j.stem.2014.05.002
[Indexed for MEDLINE]
Free PMC Article

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