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Cell Stem Cell. 2014 Jun 5;14(6):697-9. doi: 10.1016/j.stem.2014.05.001.

Common ground: stem cell approaches find shared pathways underlying ALS.

Author information

1
Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Independencia 1027, Chile; Neurounion Biomedical Foundation, Santiago, Chile. Electronic address: soledad.matus@neurounion.com.
2
Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Independencia 1027, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Independencia 1027, Santiago, Chile.
3
Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Independencia 1027, Chile; Neurounion Biomedical Foundation, Santiago, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Independencia 1027, Santiago, Chile. Electronic address: chetz@med.uchile.cl.

Abstract

The development of curative therapies for genetically complex diseases such as ALS has been delayed by the lack of relevant disease models. Recent advances using induced-pluripotent-stem-cell-derived motoneurons from patients harboring distinct ALS mutations have recapitulated essential disease features and have identified some common pathways driving disease pathogenesis.

PMID:
24905158
DOI:
10.1016/j.stem.2014.05.001
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