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Iran J Basic Med Sci. 2014;17(4):307-11.

Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice.

Author information

1
Department of Zoology, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi 221005, India.

Abstract

OBJECTIVES:

Bacopa monnieri (BM), a traditional ayurvedic medicine, is a well-known memory enhancer. We have explored the role of BM against decabrominated diphenyl ether (PBDE-209)-induced alterations in neonate and young female mice.

MATERIALS AND METHODS:

Mice were orally administered with B. monnieri at the doses of 40, 80 or 120 mg/kg body weight along with PBDE-209 (20 mg/kg body weight) from postnatal day (PND) 3-10. Levels of malondialdehyde, protein carbonyl and activities of superoxide dismutase and glutathione peroxidase were measured at both ages. The correct choices and reference/working memory errors of young mice were evaluated by Morris water and radial arm maze.

RESULTS:

The results showed that BM at the dose of 120 mg/kg significantly (P<0.05) restored the levels of oxidants and the activities of antioxidant enzymes in frontal cortex and hippocampus of neonates against PBDE-209-induced toxicity.

CONCLUSION:

BM plays a neuroprotective role against PBDE-209-induced alterations in oxidative status.

KEYWORDS:

Bacopa monnieri; Oxidative stress; PBDE-209; Reference memory; Working memory

PMID:
24904725
PMCID:
PMC4046233

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