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Science. 2014 Jun 6;344(6188):1168-1173. doi: 10.1126/science.1252806.

The sheep genome illuminates biology of the rumen and lipid metabolism.

Author information

1
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
2
CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.
3
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
4
BGI-Shenzhen, Shenzhen 518083, China.
5
Ediburgh Genomics, University of Edinburgh, Easter Bush, Midlothian EH 25 9RG, UK.
6
Department of Veterinary Science, University of Melbourne, Victoria 3010, Australia.
7
INRA, Laboratoire de Génétique Cellulaire, UMR 444, Castanet-Tolosan F-31326, France.
8
Utah State University, Logan, UT 84322-1435-1435, USA.
9
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
10
Inner Mongolia Agricultural University, Hohhot 010018, China.
11
Institute of ATCG, Nei Mongol Bio-Information, Hohhot, China.
12
Department of Anatomy, University of Otago, Dunedin 9054, New Zealand.
13
AgResearch, Invermay Agricultural Centre, Mosgiel 9053, New Zealand.
14
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
15
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.
16
Department of Biology, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark.
17
USDA-ARS Animal Disease Research Unit, Pullman, WA 99164 USA.
18
Department of Veterinary Microbiology & Pathology, Washington State University, Pullman, WA 99164 USA.
19
Maize Research Institute, Sichuan Agricultural University, Chengdu 611130, China.
20
Lanzhou Institute of Husbandry and Pharmaceutical Science, Lanzhou,730050,China.
21
Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
22
Biosciences KTN, The Roslin Institute, Easter Bush, Midlothian, EH25 9RG, UK.
23
School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia.
24
Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia.
25
Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
26
Macau University of Science and Technology, Macau 999078, China.
27
The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH 25 9RG, UK.
#
Contributed equally

Abstract

Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.

PMID:
24904168
PMCID:
PMC4157056
DOI:
10.1126/science.1252806
[Indexed for MEDLINE]
Free PMC Article

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