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Chem Commun (Camb). 2014 Jul 25;50(58):7803-5. doi: 10.1039/c4cc01651c.

A self-assembled conformational switch: a host-guest stabilized triple stem molecular beacon via a photoactivated and thermal regeneration mode.

Author information

1
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, China. kmwang@hnu.edu.cn.

Abstract

We present a novel strategy for construction of a conformational switch of a molecular beacon based on the combination of nucleic acid (DNA) self-assembly and reversible host-guest inclusion interaction. With the functionalized probe, the nucleic acid hybridization process can be easily controlled with a photoactivated and thermal regeneration mode.

PMID:
24903573
DOI:
10.1039/c4cc01651c
[Indexed for MEDLINE]

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