Abstract
A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method.
MeSH terms
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Chromatography, High Pressure Liquid
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Cyclization
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Isothiocyanates / chemistry*
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Pargyline / analogs & derivatives*
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Pargyline / chemistry
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Propylamines / chemistry*
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Thiazolidines / chemical synthesis
Substances
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Isothiocyanates
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Propylamines
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Thiazolidines
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propargylamine
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isothiocyanic acid
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Pargyline