Send to

Choose Destination
See comment in PubMed Commons below
Int J Gynecol Pathol. 2014 Jul;33(4):402-10. doi: 10.1097/PGP.0000000000000081.

High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer.

Author information

Departments of Obstetrics and Gynecology (S.D., C.Y.M.) Pathology (A.H., M.P.S., L.L., B.S.W.) Internal Medicine (H.K.) Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM (H.K., B.S.W).


Ovarian cancer is the leading cause of death from gynecologic cancers in the United States. Failure may be due to variable expression and/or complex interactions of growth factor receptors in individual tumors. As ErbB3-MET cooperativity is implicated in solid tumor resistance to EGFR/ErbB2 inhibitors, we evaluated expression of MET and all 4 ErbB family members in ovarian cancers. Tissue arrays were prepared from archival formalin-fixed paraffin-embedded tumor samples, including 202 ovarian carcinomas (Stage I-IV) and controls. Of 202 patient samples, only 25% were positive for EGFR and 35% for ErbB2 expression. ErbB3, ErbB4, and MET showed marked expression in 76%, 98%, and 96% of cases. Consistent with high incidence, there was no significant correlation for expression of ErbB3, ErbB4, or MET with outcome. On the basis of their high expression in the majority of cases, inhibitors targeting ErbB3, ErbB4, and/or MET may be broadly applicable as therapeutic agents in this disease.

[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins Icon for PubMed Central
    Loading ...
    Support Center