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AIDS. 2014 May 15;28(8):1181-91. doi: 10.1097/QAD.0000000000000222.

Causes of death among HIV-infected patients in France in 2010 (national survey): trends since 2000.

Author information

1
aINSERM, ISPED, Centre INSERM U897-Epidémiologie-Biostatistiques bService de Médecine Interne et Maladies Infectieuses, Hôpital Saint-André, CHU de Bordeaux cUniversity Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistiques, Bordeaux dService de Maladies Infectieuses, Hôpital Brabois, Vandoeuvre-Les-Nancy eUnité de Pathologie Infectieuse, Pôle Médecine, Hôpital Cochin, AP-HP fUniversité Paris Descartes gDepartment of Internal Medicine and Immunology, AP-HP Hôpital La Pitié-Salpêtrière hDépartement Hospitalo-universitaire I2B, UPMC Univ Paris 06, UMR 7211, Paris iINSERM-CépiDC, Le Kremlin-Bicêtre jService de Médecine Interne, Hôpital de l'Archet kUniversité de Nice-Sophia Antipolis, Nice lService des Maladies Infectieuses et Tropicales, Hôpital Purpan, Toulouse mService des Maladies Infectieuses et Tropicales, Hôpitaux Universitaires Paris Nord Val de Seine nUniversité Paris 7 oINSERM, UMR-S 1136 pSorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Paris qCHU de Bordeaux, Pole de Santé Publique, Bordeaux, France.

Abstract

OBJECTIVE:

The Mortalité 2010 survey aimed at describing the causes of death among HIV-infected patients in France in 2010 and their evolution since 2000.

DESIGN AND METHODS:

A national sample of clinical sites, providing HIV care and treatment, notified and documented deaths using a standardized questionnaire.

RESULTS:

The 90 participating wards notified 728 deaths. Median age at death was 50 years (interquartile range 45-58) and 75% were men. The main underlying causes of death were AIDS-related (25% in 2010 vs. 36% in 2005 and 47% in 2000), non-AIDS non-viral hepatitis-related malignancy (22 vs. 17 and 11%), liver-related (11 vs. 15 and 13%), cardiovascular diseases (10 vs. 8 and 7%) and non-AIDS-related infections (9 vs. 4 and 7%). Malignancies (AIDS and non-AIDS-related) accounted for a third of all causes of death. AIDS accounted for 33% of all causes of death among patients mono-infected with HIV vs. only 13% among those co-infected with hepatitis B virus or hepatitis C virus.

CONCLUSION:

In 2010, 25% of the causes of death among HIV-infected patients remained AIDS-related. Improved screening and earlier HIV treatment should lead to a smaller proportion of deaths due to AIDS. The majority of patients died of various causes, whereas their HIV infection was well controlled under treatment. Improving case management of HIV-infected patients should include a multidisciplinary approach (prevention, screening, treatment), especially in oncology. Smoking cessation should be a priority goal.

PMID:
24901259
DOI:
10.1097/QAD.0000000000000222
[Indexed for MEDLINE]

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