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Acta Physiol Hung. 2014 Jun;101(2):176-84. doi: 10.1556/APhysiol.101.2014.2.6.

GNB3 gene c.825C>T polymorphism and performance parameters in professional basketball players.

Author information

1
Trakya University Faculty of Medicine, Department of Biophysics Edirne Turkey.
2
Trakya University Faculty of Medicine, Department of Physiology Edirne Turkey.
3
Istanbul University Faculty of Medicine, Department of Sports Medicine Istanbul Turkey.
4
Istanbul University Physical Education and Sports School Istanbul Turkey.
5
Trakya University Faculty of Medicine, Department of Biostatistics Edirne Turkey.

Abstract

This study has been conducted to determine whether mean values of peak oxygen consumption (VO(2peak)), anaerobic test parameters and knee isokinetic test measurements are different among guanine nucleotide-binding protein, beta-3 (GNB3) genotype groups in a group of basketball players.

METHODS:

Seventy-two healthy male (mean age, 22.9 ± 5.3 years) basketball players from the first division of national league participated. We studied GNB3 gene c.825C>T (rs5443) polymorphism, then divided the subjects into three groups as CC (n = 21), CT (n = 35), and TT (n =1 6). Mean VO(2peak), Wingate anaerobic test results, and isokinetic knee muscle strength measurements were compared among the genotype groups.

RESULTS:

Mean VO(2peak) (60.1 ± 3.9; 56.7 ± 3.6; and 57.8 ± 3.3, respectively, p < 0.01), mean anaerobic minimum power (5.1 ± 0.4; 5.3 ± 0.5; and 4.4 v 0.5 W/kg, respectively, p < 0.001), mean anaerobic power drop (57.0 ± 6.2; 54.2 ± 6.9; and 62.9 ± 5.3%, respectively, p < 0.001) were significantly different among the study groups, CC, CT, and TT. Individuals with TT genotype exerted lower performance in terms of isokinetic knee muscle strength.

CONCLUSION:

The presence of 825T-allele may impair athletic performance and may serve as a genetic marker of low capacity for athletic performance in male basketball players.

KEYWORDS:

GNB3; VO2peak; exercise capacity; genetic polymorphism; isokinetic knee strength

PMID:
24901079
DOI:
10.1556/APhysiol.101.2014.2.6
[Indexed for MEDLINE]
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