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Aging Dis. 2014 Jun 1;5(3):212-7. doi: 10.14336/AD.2014.0500212. eCollection 2014 Jun.

Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging.

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Department of Nutrition and Food Sciences, Texas Woman's University, Denton, Texas, USA.
ReGenera Research group for Aging Intervention, Milano, Italy.


Uncontrolled continued exposure to oxidative stress is a precursor to many chronic diseases including cancer, diabetes, degenerative disorders and cardiovascular diseases. Of the many known mediators of oxidative stress, reactive oxygen species (ROS) and advanced glycation end products (AGEs) are the most studied. In the present review, we have summarized current data on the origin of circulating AGEs, discussed issues associated with reliable assessment of its steady state level, and changes in its level with age and select metabolic diseases. Lastly, we have made recommendations about life style changes that may decrease AGEs burden to promote healthy aging.


Aging; glycation; oxidative stress; reactive nitrogen species; reactive oxygen species

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