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ACS Med Chem Lett. 2013 Dec 4;5(3):255-8. doi: 10.1021/ml4003293. eCollection 2014 Mar 13.

Potent Hepatitis C Virus NS5A Inhibitors Containing a Benzidine Core.

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Department of Chemistry, College of Natural Sciences, Seoul National University , Seoul 151-747, South Korea.
Department of Life Sciences, Pohang University of Science and Technology , Pohang 790-784, South Korea.


Here we report the discovery of a series of potent hepatitis C virus (HCV) NS5A inhibitors based on the benzidine prolinamide backbone. Taking a simple synthetic route, we developed a novel inhibitor structure, which allows easy modification, and through optimization of the capping group, we identified compound 6 with highly potent anti-HCV activity. Compound 6 is nontoxic and is anticipated to be an effective HCV drug candidate.


HCV; NS5A inhibitor; antiviral agent; benzidine; structure−activity relationship

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