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ACS Med Chem Lett. 2010 Dec 2;2(2):124-9. doi: 10.1021/ml1002508. eCollection 2011 Feb 10.

Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.

Author information

1
Radius Health, Inc., 300 Technology Square, Cambridge, Massachusetts 02139, United States.
2
Obiter Research, 2809 Gemini Court, Champaign, Illinois 61822-9647, United States.
3
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, United States.
4
Cambridge Major Laboratories, Inc., W130 N10497 Washington Drive, Germantown, Wisconsin 53022, United States.

Abstract

This report describes the discovery of RAD140, a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). The characterization of RAD140 in several preclinical models of anabolic androgen action is also described.

KEYWORDS:

Androgen; Herschberger assay; SARM; cachexia; oxadiazole; primate

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