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ACS Med Chem Lett. 2011 Sep 19;2(11):809-13. doi: 10.1021/ml200126j. eCollection 2011 Nov 10.

Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity.

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Chemistry Department, Oncology, Pfizer Global Research and Development , 10770 Science Center Drive, La Jolla, California 92120, United States.

Erratum in

  • ACS Med Chem Lett. 2012 Feb 9;3(2):170. Baxi, Sangita [added].


Highly selective PI3K inhibitors with subnanomolar PI3Kα potency and greater than 7000-fold selectivity against mTOR kinase were discovered through structure-based drug design (SBDD). These tetra-substituted thiophenes were also demonstrated to have good in vitro cellular potency and good in vivo oral antitumor activity in a mouse PI3K driven NCI-H1975 xenograft tumor model. Compounds with the desired human PK predictions and good in vitro ADMET properties were also identified. In this communication, we describe the rationale behind the installation of a critical triazole moiety to maintain the intricate H-bonding network within the PI3K receptor leading to both better potency and selectivity. Furthermore, optimization of the C-4 phenyl group was exploited to maximize the compounds mTOR selectivity.


Kinase inhibitor; PI3K; antitumor activity; mTOR; thiophene; triazole

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