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Ir J Med Sci. 2015 Jun;184(2):441-7. doi: 10.1007/s11845-014-1140-1. Epub 2014 Jun 5.

Adverse drug reactions as a cause of admission to a Dublin-based university teaching hospital.

Author information

1
Royal College of Surgeons, Dublin, Ireland, davidrwalsh@rcsi.ie.

Abstract

BACKGROUND:

A meta-analysis of 25 international studies suggests that 4.2-6.0% of medical admissions are the result of an adverse drug reaction (ADR). One Irish study has found that 8.8% of admissions to a university teaching hospital were attributable to ADRs.

AIM:

To develop and evaluate a process to detect ADR-related medical admissions to a university teaching hospital in North Dublin.

METHODS:

A screening process was developed to detect ADR-related admissions based on a previous Scottish study. Having evaluated the accuracy of the screening process in a large Dublin-based university teaching hospital, the same methodology was then applied to medical admissions occurring over a 9-day period.

RESULTS:

The sensitivity and specificity of the screening process were 100 and 97%, respectively. The incidence of ADR-related hospitalization from 137 admissions was 5.1% (95% CI 1.4-8.8%). Of the ADRs, six were type A (predictable and preventable) and one was a type B (uncommon ADRs) reaction. Of the seven ADRs, two were considered to be unavoidable while five were potentially avoidable. High-risk medications namely anticoagulants, antiplatelets and antihypertensives were identified as causative medications.

CONCLUSIONS:

This study outlines the feasibility of screening for ADR-related admission in the hospital setting. ADRs constitute an important and avoidable cause of hospital admission.

PMID:
24899068
DOI:
10.1007/s11845-014-1140-1
[Indexed for MEDLINE]
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