Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS J. 2014 Aug;281(15):3315-24. doi: 10.1111/febs.12863. Epub 2014 Jul 1.

MDM2-MOF-H4K16ac axis contributes to tumorigenesis induced by Notch.

Author information

1
College of Life Sciences, Hebei United University, Tangshan, China; Central Laboratory, Cancer Institute, Tangshan People's Hospital, China.

Abstract

Identification of the epigenetic mechanisms involved in the transmission of Notch signaling is useful for personalized medicine. We observed that aberrantly high levels of Notch activity resulted in H4K16ac downregulation in hepatocellular carcinoma and breast cancer cell lines and tissues. This downregulated acetylation was a consequence of increased male on the first degradation following the upregulation of full-length murine double minute 2 in different cancer types. We observed that increases in male on the first could attenuate heterogeneity induced by aberrantly high levels of Notch activity. Our results provide new insights into the analysis and treatment of Notch-induced hepatocellular carcinoma and breast cancer.

KEYWORDS:

MDM2; MOF; Notch; acetylation; histone modification

PMID:
24898892
DOI:
10.1111/febs.12863
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center