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J Alzheimers Dis. 2014;41(3):715-7. doi: 10.3233/JAD-141137.

A nutritional approach to ameliorate altered phospholipid metabolism in Alzheimer's disease.

Author information

1
Department of Neurodegeneration and Neurobiology, Deutsches Institut für Demenzprävention, Saarland University, Homburg, Germany.
2
Nutricia Research, Utrecht, The Netherlands.
3
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
4
Radboud Alzheimer Center, Department of Geriatric Medicine, Radboud University Hospital, Nijmegen, The Netherlands.
5
Department of Neurology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
6
Department of Internal and Geriatrics Medicine, Hôpitaux de Toulouse, Toulouse, France.
7
Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.

Abstract

Recently, a biomarker panel of 10 plasma lipids, including 8 phosphatidylcholine species, was identified that could predict phenoconversion from cognitive normal aged adults to amnestic mild cognitive impairment or Alzheimer's disease (AD) within 2-3 years with >90% accuracy. The reduced levels of these plasma phospholipids could reflect altered phospholipid metabolism in the brain and periphery. We show that a 24-week nutritional intervention in drug-naïve patients with very mild to mild AD significantly increased 5 of the 7 measured biomarker phosphatidylcholine species. By providing nutrients which normally rate-limit phospholipid synthesis, this nutritional intervention could be useful in asymptomatic subjects with a plasma lipid biomarker profile prognostic of AD.

KEYWORDS:

Alzheimer's disease; membranes; nutritional intervention; phosphatidylcholine; plasma phospholipids; prognostic biomarkers; synaptic dysfunction

PMID:
24898653
DOI:
10.3233/JAD-141137
[Indexed for MEDLINE]

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