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Open Biol. 2014 Jun;4(6):130108. doi: 10.1098/rsob.130108.

TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes.

Author information

1
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
2
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK vmd20@cam.ac.uk.

Abstract

Chromosomal instability can arise from defects in chromosome-microtubule attachment. Using a variety of drug treatments, we show that TAO1 kinase is required for ensuring the normal congression of chromosomes. Depletion of TAO1 reduces the density of growing interphase and mitotic microtubules in human cells, showing TAO1's role in controlling microtubule dynamics. We demonstrate the aneugenic nature of chromosome-microtubule attachment defects in TAO1-depleted cells using an error-correction assay. Our model further strengthens the emerging paradigm that microtubule regulatory pathways are important for resolving erroneous kinetochore-microtubule attachments and maintaining the integrity of the genome, regardless of the spindle checkpoint status.

KEYWORDS:

kinetochore; microtubule; mitosis

PMID:
24898139
PMCID:
PMC4077056
DOI:
10.1098/rsob.130108
[Indexed for MEDLINE]
Free PMC Article

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