A new alkaloid from the fruit of Nandina domestica Thunb

Nat Prod Res. 2014;28(15):1159-64. doi: 10.1080/14786419.2014.921166. Epub 2014 Jun 4.

Abstract

A new steroidal alkaloid, (20S,22R,24R)-24-ethyl-3-oxocholest-4-en-22-amino, named as nandsterine (1), together with 10 known alkaloids, palmatine (2), O-methylbulbocapnine (3), nantenine (4), dehydronantenine (5), glaucine (6), didehydroglaucine (7), dehydrocorydaline (8), jatrorrhizine (9), magnoflorine (10) and berberine (11), was isolated from the fruit of Nandina domestica Thunb. Their structures were elucidated by using spectroscopic methods as well as by comparing with the published data. Compound 1 was a new class of steroidal alkaloid isolated from the family Berberidaceae, meanwhile compounds 2, 3, 6-8 and 10 were obtained from N. domestica for the first time. Compound 1 exhibited cytotoxicity against HL-60 cells (human leukaemia) with IC50 values of 52.1 μM.

Keywords: Nandina domestica Thunb; alkaloid; cytotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Aporphines / chemistry
  • Aporphines / isolation & purification
  • Aporphines / pharmacology
  • Berberidaceae / chemistry*
  • Cholestenes / chemistry
  • Cholestenes / isolation & purification*
  • Cholestenes / pharmacology
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Fruit / chemistry*
  • HL-60 Cells
  • Humans
  • Inhibitory Concentration 50
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Aporphines
  • Cholestenes
  • Drugs, Chinese Herbal
  • nandsterine
  • dehydrocorydalin
  • magnoflorine
  • glaucine
  • nantenine