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Cell Metab. 2014 Jun 3;19(6):894-5. doi: 10.1016/j.cmet.2014.05.015.

Father-son chats: inheriting stress through sperm RNA.

Author information

1
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
2
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: oliver.rando@umassmed.edu.

Abstract

Although mounting evidence in mammals suggests that certain ancestral environmental exposures can influence the phenotype in future generations, mechanisms underlying such intergenerational information transfer remain unclear. A recent report suggests that RNA isolated from sperm can inform offspring of a father's history of early life trauma (Gapp et al., 2014).

PMID:
24896534
PMCID:
PMC4131544
DOI:
10.1016/j.cmet.2014.05.015
[Indexed for MEDLINE]
Free PMC Article

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