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Front Biosci (Landmark Ed). 2014 Jun 1;19:1186-201.

Novel biomarker for prostate cancer diagnosis by MRS.

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Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida, India.


Magnetic resonance spectroscopy (MRS) is a prospective tool for characterization of the chemical composition of tissues. In vivo MRS can be used for metabolite profiling in the prostate tissue to discriminate non-invasively carcinomas and healthy prostate. In this article different prostate metabolites have been discussed and how to exploit the MRS technique for the estimation of metabolites in prostate tissue quantitatively is elucidated. Choline, citrate, creatine, myo-inositol metabolites can be considered as biomarker for localization of malignancy in the prostate and their ratio can be used for the determination of cancer tissue in the prostate gland.

[Indexed for MEDLINE]

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