Format

Send to

Choose Destination
See comment in PubMed Commons below
Biophys J. 2014 Jun 3;106(11):2474-82. doi: 10.1016/j.bpj.2014.03.050.

Probing the average local structure of biomolecules using small-angle scattering and scaling laws.

Author information

1
NIST Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, Maryland. Electronic address: max.watson@nist.gov.
2
NIST Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, Maryland. Electronic address: joseph.curtis@nist.gov.

Abstract

Small-angle neutron and x-ray scattering have become invaluable tools for probing the nanostructure of molecules in solution. It was recently shown that the definite integral of the scattering profile exhibits a scaling (power-law) behavior with respect to molecular mass. We derive the origin of this relationship, and discuss how the integrated scattering profile can be used to identify differing levels of disorder over local ≲30 Å length scales. We apply our analysis to globular and intrinsically disordered proteins.

PMID:
24896127
PMCID:
PMC4052260
DOI:
10.1016/j.bpj.2014.03.050
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center