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Biomed Res Int. 2014;2014:256879. doi: 10.1155/2014/256879. Epub 2014 May 8.

Association between oxidative stress and outcome in different subtypes of acute ischemic stroke.

Author information

1
Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta Pei Road, Niao Sung District, Kaohsiung, Taiwan.
2
Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta Pei Road, Niao Sung District, Kaohsiung, Taiwan ; Department of Biological Science, National Sun Yat-Sen University, Taiwan.
3
Department of Biological Science, National Sun Yat-Sen University, Taiwan ; Department of Neurosurgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta Pei Road, Niao Sung District, Kaohsiung, Taiwan.
4
Department of Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta Pei Road, Niao Sung District, Kaohsiung, Taiwan.
5
Department of Biological Science, National Sun Yat-Sen University, Taiwan ; Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta Pei Road, Niao Sung District, Kaohsiung, Taiwan.
6
Department of Biological Science, National Sun Yat-Sen University, Taiwan ; Department of Emergency Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta Pei Road, Niao Sung District, Kaohsiung, Taiwan.
7
Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta Pei Road, Niao Sung District, Kaohsiung, Taiwan ; Department of Neurosurgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta Pei Road, Niao Sung District, Kaohsiung, Taiwan.

Abstract

OBJECTIVES:

This study investigated serum thiobarbituric acid-reactive substances (TBARS) and free thiol levels in different subtypes of acute ischemic stroke (AIS) and evaluated their association with clinical outcomes.

METHODS:

This prospective study evaluated 100 AIS patients, including 75 with small-vessel and 25 with large-vessel diseases. Serum oxidative stress (TBARS) and antioxidant (thiol) were determined within 48 hours and days 7 and 30 after stroke. For comparison, 80 age- and sex-matched participants were evaluated as controls.

RESULTS:

Serum TBARS was significantly higher and free thiol was lower in stroke patients than in the controls on days 1 and 7 after AIS. The level of free thiol was significantly lower in the large-vessel disease than in the small-vessel disease on day 7 after stroke. Using the stepwise logistic regression model for potential variables, only stroke subtype, NIHSS score, and serum TBARS level were independently associated with three-month outcome. Higher TBARS and lower thiol levels in the acute phase of stroke were associated with poor outcome.

CONCLUSIONS:

Patients with large-vessel disease have higher oxidative stress but lower antioxidant defense compared to those with small-vessel disease after AIS. Serum TBARS level at the acute phase of stroke is a potential predictor for three-month outcome.

PMID:
24895559
PMCID:
PMC4034452
DOI:
10.1155/2014/256879
[Indexed for MEDLINE]
Free PMC Article
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