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Org Lett. 2014 Jun 20;16(12):3284-7. doi: 10.1021/ol501290p. Epub 2014 Jun 4.

Copper-catalyzed synthesis of α-trifluoromethylthio-substituted ketones.

Author information

1
Department of Chemistry, Fuzhou University , Fuzhou 350108, China.

Abstract

The CF3S-substituted moiety serves as an important structural element in many bioactive molecules. A versatile copper catalyst that allowed for trifluoromethylthiolation of primary and secondary α-bromoketones is described. The reaction with readily available elemental sulfur and CF3SiMe3 afforded a broad scope and moderate to good yields of α-trifluoromethylthio-substituted ketones. This procedure represents a very operationally simple yet powerful strategy for the synthesis of α-trifluoromethylthio-substituted ketones, a useful and versatile class of synthetic synthons.

PMID:
24894976
DOI:
10.1021/ol501290p
[Indexed for MEDLINE]

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