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J Clin Virol. 2014 Aug;60(4):422-3. doi: 10.1016/j.jcv.2014.05.003. Epub 2014 May 13.

Severe acute hepatitis E in an HIV infected patient: Successful treatment with ribavirin.

Author information

1
Service de Médecine Interne et des Maladies Infectieuses et Tropicales, CHU Robert Debré, Reims, France.
2
Service de d'hepato-gastroenterologie, CHU Robert Debré, Reims, France.
3
Laboratoire de Virologie Médicale et Moléculaire, CHU Robert Debré, Reims, France.
4
Laboratoire d'Immunologie, CHU Robert Debré, Reims, France.
5
Service d'hepato-gastroenterologie, federation digestive, Hôpital Purpan, CHU de Toulouse, Toulouse, France.
6
Laboratoire de virologie, Hôpital Purpan, CHU de Toulouse, Toulouse, France.
7
Service de Médecine Interne et des Maladies Infectieuses et Tropicales, CHU Robert Debré, Reims, France. Electronic address: fbanisadr@chu-reims.fr.

Abstract

In industrialized countries, most cases of hepatitis E virus (HEV) infection in humans are autochthonous, mainly through foodborne and zoonotic transmission routes. In Europe, genotype 3 is a cause of acute self-limiting viral hepatitis, but can also be responsible for chronic hepatitis in immunocompromised patients. Ribavirin has been successfully used in the treatment of chronic hepatitis E and in a few cases of severe acute hepatitis E in immunocompetent patients. We report here the case of a 39 year-old man infected with HIV presenting with acute hepatitis E (genotype 3c). Unlike most cases, evolution was severe with a fall of prothrombin time down to 45%. Treatment with ribavirin allowed rapid viral clearance and a gradual normalization of liver function tests.

KEYWORDS:

Acute hepatitis E; HEV; HIV infection; Ribavirin

PMID:
24894604
DOI:
10.1016/j.jcv.2014.05.003
[Indexed for MEDLINE]

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